"The Flintstones", some sources stated athat it jumped during the third season when Fred Flintstone's "Jackie Gleason-esque" personaliy have toned down when Pebbles was born. Honestly, the writers were probably mirroring reality since most people actually changed when becoming parents.
I tend to cringe on the episode where Pebbles & Bamm Bamm becomes a singing duo, which I think was on the third or fourth season...
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Married with Children"... when Seven joined the series
Ironically Ted McGinley joining is considered "shark jumping", but Jefferson D'Arcy, his character, was a good addition to the cast.
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Headbanger's Ball", when alternative videos from Nirvana & Alice In Chains were shown in the early 1990's. Change of the musical climate.
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E! True Hollywood Story", when it focused more on young Hollywood
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Ren & Stimpy Show", while many sources have stated that the show jumped when creator/voice of Ren John Kricfalusi was fired, there's still some memorable episodes from the last three seasons including "Ren's Bitter Half" and the one where they come across a baboon. Ironically, the wretched revival "Adult Party Cartoon" was actually done by the original creator...
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In Living Color", don't think it jumped. Especially during the fifth season with a few of the original cast. It was thankfully cancelled since it might've ended up like "SNL" or "Mad TV". Though "SNL" was back on top again during the early 1990's with Phil Hartman, David Spade, Adam Sandler, Chris Rock, Mike Myers etc.
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Drawn Together", from the get go since it relied too much on shock humor and tried too hard to be funny. Though a reality show parody with cartoon characters (parodied or made up) from different universes/backgrounds would've made an OK show.
Betty Boop, when the Hayes Code came in full effect in 1934 since Betty was toned down and jazz music could nolonger be used for the soundtrack. Though the flapper style was also phasing (or already phased) out by the mid 1930's.
Fleischer Studios would also crumble & end up trying to keep up with Disney (ie the movie "Gulliver's Travel" & 'Color Classics' shorts) until Paramount took over and renamed it Famous Studios in 1942. Though had success with Popeye and Superman shorts.
Not much into Fleischer cartoons, though I'll admit that some of the early Betty Boop cartoons were enjoyable eye candy. Though always thought Popeye was very hit or miss. Famous Studios...I'll admit that there's a few decent shorts like "Much Ado About Mutton" and "Butterscotch & Soda".
Tom & Jerry, when Bill Hanna & Joesph Barbera stopped producing the cartoons and left MGM when the animation studios folded in 1957. The later incarnations such as the theatricals from Gene Deitch & Chuck Jones and the corny, politically correct tv garbage from the '70's (
ironically from Hanna Barbera) doesn't come close to the cartoons from the 1940's/1950's.
Don't mind the introduction of the baby duck, though don't think many cartoons were made with that character. Probably due to overexposure on television.
Droopy, when Tex Avery left MGM in 1953 and also the character's design also was given a face lift in the early 1950's.
Looney Tunes, when the Warner Bros. animation studio closed in 1964, with the remaining top directors Friz Freleng & Chuck Jones leaving for other projects. For some reason it opened shop again until 1969 and produced some forgettable cartoons like the unnecessary pairing of Daffy Duck & Speedy Gonzales.
For some reason, the animation (in general) became limited by the 1950's though Looney Tunes peaked around
1957 since most of the cartoons after were very hit & miss.
Characters:
Tweety, when joined Sylvester since the sadistic canary from the early 1940's was toned down and became less dependant, which he would have to rely on Granny or the bulldog, during the mid 1950's.
Elmer Fudd, when Arthur Q. Bryan passed in 1958
Bugs, when he became more calm & smug by the end of the 1950's and bland later on television specials and film appearances.
Daffy, when director Chuck Jones made the character greedy in the 1950's. Granted that there's memorable cartoons feauring the greedy duck like the hunting trilogy with Elmer & Bugs, but turned into a fall guy for no real reason in "Show Biz Bigs" (directed by Friz Freleng).